PROTAC IRAK4 degrader-12 - CAS 2919995-09-6

PROTAC IRAK4 degrader-12, a Cereblon ligand-based PROTAC, induces a maximum degradation of IRAK4 in K562 cells at 108.46% with an IC50 value of 4.87 nM. (Structure Note: Pink, IRAK4 Inhibitor; Blue, E3; Black, linker.)

PROTACs, IRAK

PROTAC, NF-κB, Immunology/Inflammation

2919995-09-6

C46H50ClF2N11O6

926.41

N(C(CN1CCN(C[C@H]2CC[C@@H](CC2)N3C=C(NC(=O)C=4N=C(OC4)C=5C=C(NCC6CC6)N=CC5)C(C(F)F)=N3)CC1)=O)C7=C8C(C=9C(=NOC9C=C8)C%10C(=O)NC(=O)CC%10)=CC=C7.Cl

-20°C

Ice Packs

Small Compound