PROTAC IRAK4 degrader-2 - CAS 2374122-27-5

PROTAC IRAK4 Degrader-2 (Compound 9) is a PROTAC-based degrader that potently reduces IRAK4 levels, achieving a DC50 of 151 nM in peripheral blood mononuclear cells (PBMCs) . It also notably decreases IRAK4 protein levels with a DC50 of 36 nM in the same cell type and inhibits several cytokines in PBMCs [1].

Others, PROTACs, IRAK

PROTAC, Others, NF-κB, Immunology/Inflammation

2374090

C57H68FN11O8S

1086.28

CC[C@H]1[C@@H](COc2ncc(C#CCN3CCC4(CC3)CCN(CC4)c3ncc(cn3)C(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(cc3)-c3scnc3C)C(C)(C)C)c3cc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F

-20°C

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