PROTAC K-Ras Degrader-2 - CAS 3043670-74-9

PROTAC K-Ras degrader-2 (compound 48) is a broad-spectrum KRAS mutant PROTAC degrader that demonstrates an IC50 of ≤200 nM for KRAS G12V/RAF1. Additionally, PROTAC K-Ras degrader-2 achieves a DC50 of ≤200 nM in degrading SW620 KRAS G12D and inhibits the growth of SW620 3D cells with an IC50 of ≤20 nM.

PROTACs, Ras, Kras

GPCR/G Protein, MAPK, PROTAC

3043587

C52H60F4N8O5

953.077

C(C1(COC=2N=C(C3=C(N2)C(F)=C(N=C3)C=4C5=C(C=C(O)C4)C=CC(F)=C5CC)N6C[C@](C)(O)CCC6)CC1)N7CCC(CN8CCN(CC8)C9=CC(F)=C(C(F)=C9)C%10C(=O)NC(=O)CC%10)(C)CC7

-20°C

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PROTAC