PROTAC K-Ras Degrader-5 - CAS 3052745-16-8

Pan-KRAS degrader 4 (compound 69) is a cereblon-based PROTAC KRAS degrader exhibiting anticancer activity with a DC50 value of less than 100 nM.

DNA/RNA Synthesis, Ras, PROTACs

PROTAC, MAPK, GPCR/G Protein, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

3052721

C57H63F3N10O5

1025.17

O=C1C2=CC=C(C(F)=C2CN1C3C(=O)NC(=O)CC3)N4CCC(CN5CCC(CC5)CC6CCN(CCOC7=NC8=C(F)C(=NC=C8C(=N7)N9CC%10NC(C9)CC%10)C=%11C=C(O)C=C%12C=CC(F)=C(C#C)C%12%11)CC6)CC4

-20°C

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