PROTAC K-Ras Degrader-6 - CAS 3052745-46-4

Pan-KRAS degrader 5 (compound 102) is a cereblon-based PROTAC KRAS degrader with a DC50 value less than 100 nM, exhibiting anticancer activity.

PROTACs, Ras, Antibacterial

Microbiology/Virology, MAPK, GPCR/G Protein, PROTAC

3052695

C57H65F2N11O5

1022.19

O=C1NC(=O)C(N2C(=O)N(C3=CC(=CC=C32)N4CCC(CN5CCC(CC5)CC6CCN(CCOC7=NC8=C(F)C(=NC=C8C(=N7)N9CC%10NC(C9)CC%10)C=%11C=C(O)C=C%12C=CC(F)=C(C#C)C%12%11)CC6)CC4)C)CC1

-20°C

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