PROTAC KRAS G12C degrader-2 - CAS 2378257-72-6

PROTAC KRAS G12C degrader-2 (compound 432) acts as a bifunctional modulator, enhancing the hydrolysis of K-Ras protein. One end of this compound features a cereblon inhibitor of apoptosis proteins (IAP), while the other end contains a moiety that binds to KRAS [1].

PROTACs, Ras, Kras

GPCR/G Protein, PROTAC, MAPK

2378257-72-6

C51H53ClFN9O7

958.47

FC=1C2=C(C(=NC(O[C@@H](CN3CCN(CC4CCN(CC4)C=5C=C6C(=CC5)C(=O)N(C6=O)C7C(=O)NC(=O)CC7)CC3)C)=N2)N8CCN(C(C=C)=O)CC8)C=C(Cl)C1C=9C%10=C(C=C(O)C9)C=CC=C%10

-20°C

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PROTAC