PROTAC KRAS G12D degrader 1 - CAS 3033583-54-6

PROTACKRAS G12D degrader 1 is a potent, rapid, and selective degrader of PROTACKRASG12D, with a DC50 of 38.06 nM. It demonstrates significant antitumor efficacy.

PROTACs

PROTAC

3033523

C59H72F2N10O7S

1103.33

C(C)C=1C=2C(=CC(O)=CC2C=CC1F)C3=C(F)C4=C(C=N3)C(=NC(OC[C@H]5N(CCCCOCC(N[C@H](C(=O)N6[C@H](C(N[C@@H](C)C7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)CCC5)=N4)N9CC%10NC(C9)CC%10

-20°C

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