PROTAC LZK-IN-1 - CAS 2763268-64-8

PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13) . At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.

PROTACs, c-Myc, MAP3K, MAPK, MDM-2/p53

PROTAC, Apoptosis, MAPK, Cell Cycle/Checkpoint

2763196

C51H64F2N10O5S

967.18

C([C@@H](NC(CCCCCCC(=O)N1CCC(CC1)C=2C=C(N=C(NC3=CC(C#N)=CC=N3)C2)N4CCC(F)(F)C4)=O)C(C)(C)C)(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@@H](O)C5

-20°C

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PROTAC