PROTAC MEK1 Degrader-1 - CAS 2671004-41-2

PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2 phosphorylation. With a pIC50 value of 7.0, it exhibits antiproliferative activity against A375 cells [1].

PROTACs, MEK, ERK

PROTAC, MAPK

2670961

C53H66FIN8O11S2

1201.17

N(C1=C(NS(=O)(=O)C2=CC=C(CCC(NCCOCCOCCOCC(N[C@H](C(=O)N3[C@H](C(N[C@@H](C)C4=CC=C(C=C4)C=5SC=NC5C)=O)C[C@@H](O)C3)C(C)(C)C)=O)=O)C=C2)C=C(C)C(=O)N1C)C6=C(F)C=C(I)C=C6

-20°C

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