PROTAC pan-KRAS degrader-1 - CAS 3043908-63-7

PROTACpan-KRAS degrader-1 is a pan-KRAS PROTAC degrader that targets multiple KRAS mutants, including G12D, G12C, G12V, and G13D. It effectively degrades the KRAS mutant (G12D) in AGS cells, with a DC50 of 1.1 nM and a Dmax of 95%. This compound can be used in studies of diseases caused by KRAS mutations or amplifications, particularly in cancers such as breast, bladder, and gastric cancer.

Ras, PROTACs

PROTAC, MAPK

3043838

C63H71F2N13O7S

1192.38

C(C1(COC=2N=C(C3=C(N2)C(F)=C(N=C3)C=4C5=C(C=C(O)C4)C=CC(F)=C5CC)N6C[C@](C)(O)CCC6)CC1)N7CCC(OC=8C=NC(=CN8)C9=CN([C@H](C(=O)N%10[C@H](C(N[C@@H](C)C%11=CC=C(C=C%11)C%12=C(C)N=CS%12)=O)C[C@@H](O)C%10)C(C)C)N=N9)CC7

-20°C

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PROTAC