PROTAC PARP1 degrader - CAS 2369022-68-2

PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μM) .

Others, PROTACs, PARP

DNA Damage/DNA Repair, Chromatin/Epigenetic, PROTAC, Others

2368952

C58H63Cl2N11O10

1145.1

C(=O)(N1[C@]([C@](N=C1C2=C(OC(C)C)C=C(OC)C=C2)(C3=CC=C(Cl)C=C3)[H])(C4=CC=C(Cl)C=C4)[H])N5CC(=O)N(CC(NCCOCCOCCOCCOCCN6C=C(N=N6)C7=CC=C(C=C7)N8N=C9C(=C8)C=CC=C9C(N)=O)=O)CC5

-20°C

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PROTAC