PROTAC RAR Degrader-1 - CAS 1351169-27-1

PROTAC RAR Degrader-1, an RAR degrader, consists of a cIAP1 ligand binding group, a linker, and an RAR ligand binding group. It achieves maximal RAR degradation at a concentration of 30 μM in HT1080 cells. Degradation inducers that utilize cIAP1 are known as specific and non-genetic IAP-dependent protein erasers (SNIPERs) [1].

SNIPERs, PROTACs, Retinoid Receptor

PROTAC, Metabolism

1351141

C51H72N4O11

917.14

O(CCCNC(COCCOCCOCCNC([C@@H](NC([C@H]([C@@H](CC1=CC=CC=C1)N)O)=O)CC(C)C)=O)=O)C2=C(C(O)=O)C=CC(/C=C/C(=O)C3=CC(C(C)(C)C)=CC(C(C)(C)C)=C3)=C2

-20°C

Ice Packs

PROTAC