PROTAC sEH-degrader-3 - CAS 3093413-94-3

PROTACsEH-degrader-3 (Compound 1a) is a targeted sEH PROTAC degrader that selectively degrades cytosolic sEH without affecting sEH in peroxisomes. It degrades sEH through a CRBN-dependent lysosomal pathway rather than the proteasomal pathway, with an IC50 of 0.8 nM for hsEH. Additionally, PROTACsEH-degrader-3 inhibits endoplasmic reticulum stress, making it useful for research on diseases related to inflammation, metabolic disorders, and other conditions associated with endoplasmic reticulum stress.

Epoxide Hydrolase, PROTACs

Metabolism, PROTAC

3093316

C46H53F3N6O14

970.94

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-20°C

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PROTAC