PROTAC SGK3 degrader-2 - CAS 2381196-78-5

PROTACSGK3degrader-2 is the cis-diastereomer of PROTACSGK3degrader-1 (SGK3-PROTAC1), featuring a cis-hydroxy group in its VH032 section, which prevents binding to the VHL E3 ligase. This compound inhibits SGK3, SGK1, and S6K1 with IC50 values of 0.6 μM, 1.4 μM, and 1.7 μM, respectively, but does not degrade SGK3. It serves as a control compound for studying the specific degradation effects mediated by SGK3-PROTAC1.

PROTACs, SGK

Metabolism, PROTAC

2381113

C57H73FN10O11S2

1157.38

O(C[C@H]1CN(CCCCCCOCCOCCOCC(N[C@H](C(=O)N2[C@H](C(NCC3=CC=C(C=C3)C4=C(C)N=CS4)=O)C[C@H](O)C2)C(C)(C)C)=O)CCO1)C=5N=C(N=C6C5C=NN6)C7=CC=C(NS(=O)(=O)C8=C(F)C=CC(C)=C8)C=C7

-20°C

Ice Packs

PROTAC