PROTAC Sirt2 Degrader-1 - CAS 2098487-75-1

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC that acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM) [1].

PROTACs, Sirtuin

DNA Damage/DNA Repair, Chromatin/Epigenetic, PROTAC

2098411

C40H40N10O8S2

852.94

Cc1cc(C)nc(SCC(=O)Nc2ncc(Cc3cccc(OCc4cn(CCCCNC(=O)COc5cccc6C(=O)N(C7CCC(=O)NC7=O)C(=O)c56)nn4)c3)s2)n1

-20°C

Ice Packs

PROTAC