PROTAC SMARCA2/4-degrader-1 - CAS 2568273-68-5

Compound I-430, known as SMARCA2/4-degrader-1, is a PROTAC degrader targeting SMARCA2 and SMARCA4. In A549 cells, it achieves degradation of SMARCA2/4 proteins with DC50s values under 100 nM and demonstrates a maximal degradation rate (Dmax%) exceeding 90% after a 24-hour treatment.

PROTACs

PROTAC

2568200

C51H62N12O6S

971.18

NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)[C@H]5CC[C@H](C(N[C@H](C(=O)N6[C@H](C(NCC7=C(NC(C)=O)C=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)CC5)C=C(N=N1)C9=C(O)C=CC=C9

-20°C

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PROTAC