PROTAC SMARCA2/4-degrader-7 - CAS 2568277-89-2

Compound I-439, also known as SMARCA2/4-degrader-7, is a PROTAC degrader targeting SMARCA2 and SMARCA4. In A549 cells, it degrades SMARCA2/4 proteins with DC50s values less than 100 nM and achieves a maximum degradation rate (Dmax%) exceeding 90% after a 24-hour treatment.

PROTACs

PROTAC

2568186

C51H61N11O5S

940.17

N(C(=O)[C@H]1N(C([C@@H](NC(=O)[C@@H]2CC[C@H](CC2)C=3C=NC(=NC3)N4C5CN(CC4CC5)C=6C=C(N=NC6N)C7=C(O)C=CC=C7)C(C)(C)C)=O)C[C@H](O)C1)C8(CC8)C9=CC=C(C=C9)C%10=C(C)N=CS%10

-20°C

Ice Packs

PROTAC