PROTAC SMARCA2 degrader-1 - CAS 2892523-73-6

PROTACSMARCA2 degrader-1 (compound ex7) is a potent BRM (SMARCA2) degrader with a DC50 of less than 0.1 μM. It functions as a linker for E3 ubiquitin ligase, making it useful in cancer research, and is a conjugate of a target protein ligand and linker.

Target Protein Ligand-Linker Conjugate

PROTAC

2892444

C49H62N10O6S

919.15

C(N1CC2(NC=3C(NC2)=NN=C(C3)C4=C(O)C=CC=C4)CCC1)C5CCN(CCOC=6C=C([C@H](C(=O)N7[C@H](C(N[C@@H](C)C8=CC=C(C=C8)C=9SC=NC9C)=O)C[C@@H](O)C7)C(C)C)ON6)CC5

-20°C

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PROTAC