PROTAC SMARCA2 degrader-10 - CAS 2568279-34-3

PROTAC SMARCA2 degrader-10 (compound I-507) is a targeted degrader of SMARCA2, demonstrating a DC50 of less than 100 nM in A549 cells, with a maximum degradation rate (Dmax%) exceeding 90% after 24 hours of treatment.

PROTACs

PROTAC

2568242

C55H60N10O5S

973.19

C([C@@H](NC(=O)C1=CC=C(C=C1)C2=CC=C(CN3CCC(CN4C=C(C=N4)C=5C=C(N=NC5N)C6=C(O)C=CC=C6)CC3)C=C2)C(C)(C)C)(=O)N7[C@H](C(NCC8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7

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