PROTAC SMARCA2 degrader-13 - CAS 2568276-72-0

SMARCA2 degrader-2 (compound I-322) is a PROTAC degrader targeting SMARCA2; it achieves a DC50 of less than 100 nM for the degradation of SMARCA2 protein in A549 cells, with a maximum degradation rate (Dmax%) exceeding 90% after 24 hours of treatment.

PROTACs

PROTAC

2568204

C37H39N9O5

689.76

O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NC4CCC(N5CCC(N6N=CC(=C6)C=7C=C(N=NC7N)C=8C=CC=CC8O)CC5)CC4)C3C2=O)CC1

-20°C

Ice Packs

PROTAC