PROTAC SMARCA2 degrader-16 - CAS 2568276-37-7

PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC targeting SMARCA2. It demonstrates degradation of the SMARCA2 protein with a DC50<100 nM in A549 cells, achieving a maximal degradation rate (Dmax%) of over 90% after 24 hours of treatment.

PROTACs

PROTAC

2568232

C41H47N11O4

757.88

O=C1NC(=O)C(N2C(=O)N(C3=CC(=CC=C32)CCCN4CCC(C5=NC=CC(=N5)N6C7CN(C=8C=C(N=NC8N)C9=CC=CC=C9O)CC6CC7)CC4)C)CC1

-20°C

Ice Packs

PROTAC