PROTAC SMARCA2 degrader-19 - CAS 2567913-00-0

PROTAC SMARCA2 degrader-19 (Compound 46) acts as a degrader of SMARCA2, demonstrating degradation capabilities in A549 and MV411 cells with a DC50 of less than 100 nM. Additionally, this compound degrades SMARCA4 in MV411 cells, but with a significantly higher DC50 of over 1000 nM.

Epigenetic Reader Domain, PROTACs

PROTAC, Chromatin/Epigenetic

2567913-00-0

C50H58N10O5S

911.13

OC1=C(C=2C=C3C(=CNC3=NN2)C4CCN(CC4)C=5N=CC(=CN5)[C@@H]6CC[C@@H](C(N[C@H](C(=O)N7[C@H](C(NCC8=CC=C(C=C8)C=9SC=NC9C)=O)C[C@@H](O)C7)[C@](C)(C)C)=O)CC6)C=CC=C1

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