PROTAC SMARCA2 degrader-2 - CAS 2892523-74-7

PROTAC SMARCA2 degrader-2, a selective and powerful degrader of SMARCA2/4, exhibits an IC50 of <0.1 μΜ in the HeLa HiBiT assay.this compound holds promise for research into cancers related to or deficient in SMARCA4 [1].

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2892523-74-7

C49H62N10O6S

919.15

C(N1CCC2(NC=3C(NC2)=NN=C(C3)C4=C(O)C=CC=C4)CC1)C5CCN(CCOC=6C=C([C@H](C(=O)N7[C@H](C(N[C@@H](C)C8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7)C(C)C)ON6)CC5

-20°C

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