PROTAC SMARCA2 degrader-21 - CAS 2891464-61-0

PROTAC SMARCA2 degrader-21 (Compound I-5) acts as a degrader of SMARCA2 in A549 cells, with a DC50 range of 10-50 nM, and additionally degrades both SMARCA2 and SMARCA4 in MV411 cells, with respective DC50 values of <1 nM and >100 nM.

PROTACs, Epigenetic Reader Domain

Chromatin/Epigenetic, PROTAC

2891403

C54H66N12O5S

995.24

O=C(NCC=1C=CC(=CC1)C=2SC=NC2C)C3N(C(=O)C(NC(=O)C4CC5(C4)CC(N6CCC(C7=NC(=NC=C7)N8CCN9C%10=CC(=NN=C%10NCC9C8)C=%11C=CC=CC%11O)CC6)C5)C(C)(C)C)CC(O)C3

-20°C

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