PROTAC SMARCA2 degrader-28 - CAS 2641510-88-3

PROTAC SMARCA2 degrader-28 (Compound 158) is a potent SMARCA2 PROTAC degrader that achieves degradation of SMARCA2 in HiBiT A549 cells, exhibiting a DC50 of 3 nM.

PROTACs, Epigenetic Reader Domain

PROTAC, Chromatin/Epigenetic

2641419

C50H51F7N10O10

1084.99

O=C(C(F)(F)F)O.O=C1C2=CC=C(N3CCC(CC3)C(N4CCN(CC4)CC5=CC(N6C7CN(CC6CC7)C8=C(N)N=NC(C9=CC(F)=CC=C9O)=C8)=CC=C5)=O)C=C2C(N1C%10C(NC(CC%10)=O)=O)=O.O=C(C(F)(F)F)O

-20°C

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