PROTAC SMARCA2 degrader-6 - CAS 2568523-72-6

PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC molecule targeting SMARCA2, exhibiting a DC50 of less than 100 nM and a maximum degradation rate (Dmax%) of over 90% in A549 cells after 24 hours of treatment.

PROTACs

PROTAC

2568445

C56H70N12O5S

1023.3

O=C(NCC=1C=CC(=CC1)C=2SC=NC2C)C3N(C(=O)C(NC(=O)C4CC5(C4)CC(CN6CCC(C7=CN=C(N=C7)N8C9CN(C=%10C=C(N=NC%10N)C%11=CC=CC=C%11O)CC8CC9)CC6)C5)C(C)(C)C)CC(O)C3

-20°C

Ice Packs

PROTAC