PROTAC SMARCA2 degrader-9 - CAS 2568276-39-9

PROTAC SMARCA2 degrader-9 (compound I-285) is a PROTAC degrader targeting SMARCA2. It degrades SMARCA2 protein in A549 cells with a DC50 value of less than 100 nM and achieves a maximum degradation rate (Dmax%) of over 90% after 24 hours of treatment.

PROTACs

PROTAC

2568228

C40H46N12O4

758.87

O=C1NC(=O)C(N2C(=O)N(C3=CC(=CC=C32)CCCN4CCN(C5=CN=C(N=C5)N6C7CN(C=8C=C(N=NC8N)C9=CC=CC=C9O)CC6CC7)CC4)C)CC1

-20°C

Ice Packs

PROTAC