PROTAC SOS1 degrader-5 - CAS 2836273-61-9

PROTAC SOS1 degrader-5 (compound 4) serves as an effective degrader of PROTAC SOS1, exhibiting a DC50 of 13 nM. It robustly suppresses the proliferation of NCI-H358 cells, with an IC50 value of 5 nM [1].

Ras, PROTACs

MAPK, PROTAC, GPCR/G Protein

2836273-61-9

C45H51F3N8O7

872.93

C(OC1=CC2=C(C=C1OC)N=C(C)N=C2N[C@H](C)C3=CC(C(F)(F)F)=CC(N)=C3)C4(CN(C(CCCCCCNC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)=O)C)CC4

-20°C

Ice Packs

PROTAC