PROTAC TTK degrader-1 - CAS 2953426-43-0

PROTAC TTK degrader-1, a potent threonine tyrosine kinase (TTK) PROTAC degrader, demonstrates DC50 values of 1.7 nM in COLO-205 cells and 5.8 nM in HCT-116 cells, indicating effective target degradation. Furthermore, it shows anticancer efficacy in a xenograft mouse model with COLO-205 human colorectal cancer cells [1].

PROTACs

PROTAC

2953426-43-0

C47H53N9O7

855.98

O=C1N(C=2C(=CN=C(NC3=C(OC)C=C(C=C3)N4CCN(C(CCCC#CC=5C=C6C(=CC5)C(=O)N(C6)C7C(=O)NC(=O)CC7)=O)CC4)N2)C(C)=C1)[C@H]8CC[C@@H](NC(CC)=O)CC8

-20°C

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PROTAC