PROTAC TTK degrader-2 - CAS 2953426-48-5

PROTAC TTK Degrader-2 is a potent threonine tyrosine kinase (TTK) PROTAC degrader, achieving DC50 values of 3.1 nM in COLO-205 cells and 12.4 nM in HCT-116 cells. It demonstrates effective target degradation and anticancer activity in a COLO-205 human colorectal cancer cell xenograft mouse model [1].

PROTACs

PROTAC

2953426-48-5

C49H57N9O7

884.03

O=C1N(C=2C(=CN=C(NC3=C(OC)C=C(C=C3)N4CCN(C(CCCCCC#CC=5C=C6C(=CC5)CN(C6=O)C7C(=O)NC(=O)CC7)=O)CC4)N2)C(C)=C1)[C@H]8CC[C@@H](NC(CC)=O)CC8

-20°C

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PROTAC