Protosappanin A - CAS 102036-28-2

Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎoB/NF-ÎoB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.

NF-κB, HIV Protease, IκB/IKK, NADPH-oxidase, IL Receptor, JAK, COX, STAT, ROS, Interleukin, TLR, TNF, NO Synthase

Neuroscience, Microbiology/Virology, NF-κB, Tyrosine Kinase/Adaptors, Stem Cells, Chromatin/Epigenetic, Apoptosis, Proteases/Proteasome, JAK/STAT signaling, Immunology/Inflammation, Angiogenesis

102036-28-2

>99.99%

C15H12O5

272.25

Oc1ccc-2c(OCC(=O)Cc3cc(O)c(O)cc-23)c1

-20°C

Ice Packs

Natural Product