PRT543 - CAS 1989620-03-2

PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.

Others, Histone Methyltransferase

Chromatin/Epigenetic, Others

1989620-03-2

C17H17ClN4O4

376.79

O[C@H]1[C@H](N2C=3C(C=C2)=C(N)N=CN3)O[C@]([C@H](O)C4=CC=C(Cl)C=C4)([C@H]1O)[H]

-20°C

Ice Packs

Small Compound