PS315 - CAS 1221964-50-6

PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM) . PS315 has anti-cancer activity. PS315 is a derivative of PS48 and is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing displacement of the active site residue Lys111.

PKC

Cytoskeletal Signaling, Chromatin/Epigenetic

1221908

C23H19ClO2

362.85

C(\CCC1=CC=C(Cl)C=C1)(=C/C(O)=O)/C2=CC=C(C=C2)C3=CC=CC=C3

-20°C

Ice Packs

Small Compound