Psammaplin A - CAS 110659-91-1

Psammaplin A, a marine metabolite, functions as a robust inhibitor of HDAC and DNA methyltransferases, displaying notable potency and selectivity as a DAC1 inhibitor, with an IC50 value of 0.9 nM. It exhibits antimicrobial effects against Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity, demonstrating antitumor activity [1][2].

Antibacterial, HDAC, DNA Methyltransferase, DNA/RNA Synthesis, Others

Cell Cycle/Checkpoint, Microbiology/Virology, DNA Damage/DNA Repair, Chromatin/Epigenetic, Others

110567

C22H24Br2N4O6S2

664.38

O\N=C(/Cc1ccc(O)c(Br)c1)C(=O)NCCSSCCNC(=O)C(\Cc1ccc(O)c(Br)c1)=N\O

-20°C

Ice Packs

Natural Product