PT-65 - CAS 2721998-87-2

PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].

Others, GSK-3, PROTACs

PI3K/Akt/mTOR signaling, Others, Stem Cells, PROTAC

2721998-87-2

C51H63N13O12S

1082.19

O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCOCCOCCOCCN4C=C(CCCCN5CCN(S(=O)(=O)C6=CC=C(C=C6)C7=NC(C(NC=8C=CC=NC8)=O)=C(N)N=C7)CC5)N=N4

-20°C

Ice Packs

Small Compound