PT4 - CAS 1280738-47-7

PT4 is a treatment agent for Cutaneous leishmaniasis (CL) . PT4 decreases of mitochondrial membrane potential and increases reactive oxygen species production, therefore leads to parasite death. PT4 is effective against both species of Leishmania. The IC50 values of PT4 against L. amazonensis and L. braziliensis are 125.18 and 233.18 μM , respectively. PT4 also shows potent anti-inflammatory activity in vivo [1].

Others, Parasite, Reactive Oxygen Species

NF-κB, Others, Metabolism, Immunology/Inflammation, Microbiology/Virology

1280684

C18H14N4O2

318.33

O=C1C=2C(C(=O)N1CCN3C=C(N=N3)C4=CC=CC=C4)=CC=CC2

-20°C

Ice Packs

Small Compound