PTC299 - CAS 1256565-36-2

PTC299 ((4-chlorophenyl) (1S) -6-chloro-1- (4-methoxyphenyl) -1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA translation and selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydrolactate dehydrogenase (DHODH) .

DNA/RNA Synthesis, VEGFR, Dehydrogenase

Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors, DNA Damage/DNA Repair, Angiogenesis, Metabolism

1256527

0.9972

C25H20Cl2N2O3

467.34

COc1ccc(cc1)[C@@H]1N(CCc2c1[nH]c1ccc(Cl)cc21)C(=O)Oc1ccc(Cl)cc1

-20°C

Ice Packs

Small Compound