PTD10 - CAS 2642231-19-2

PTD10 is a BTK-targeting PROTAC degradator (DC50=0.5 nM, KD=2.28 nM) that induces apoptosis via caspase-dependent and mitochondrial pathways, suitable for studying B-cell dysregulation.

PROTACs, Apoptosis, BTK

Angiogenesis, Tyrosine Kinase/Adaptors, Apoptosis, PROTAC

2642210

0.9912

C49H51N11O8

922.99

O=C1C=2N(C3=C(C2)CC(C)(C)C3)CCN1C4=C(CO)C(=CC=N4)C=5C=C(NC6=CC=C(C=N6)N7[C@@H](C)CN(C(CNC8=C9C(C(=O)N(C9=O)C%10C(=O)NC(=O)CC%10)=CC=C8)=O)CC7)C(=O)N(C)C5

-20°C

Ice Packs

PROTAC