PTK7/β-catenin-IN-2 - CAS 902434-29-1

PTK7/β-catenin-IN-2 (compound 04967) acts as an inhibitor targeting both PTK7 and β-catenin, effectively preventing their interaction with an IC 50 of 5.6 μM and disrupting the Wnt/β-catenin signaling pathway. This interference supports its role in inhibiting cell growth reliant on Wnt signaling, exhibiting anticancer capabilities. Additionally, the compound displays an inhibitory effect on the binding of p53 to MDM2, with an IC 50 value of 157.1 μM [1].

Wnt/beta-catenin

Cytoskeletal Signaling, Stem Cells

902434-29-1

C30H34Cl2N6O

565.54

CC=1N2C(=CC(=N2)C3=CC=C(Cl)C=C3)N=C(C)C1CCC(NCCCN4CCN(CC4)C5=CC(Cl)=CC=C5)=O

-20°C

Ice Packs

Small Compound