PU-H71 HCl - CAS 2095432-24-7

PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of malignancy. PU-H71 HCL has an inhibitory effect on the protein expression levels of Rad51 and Ku70, which may be associated with the double chain break repair in the homologous recombination pathway and non-homologous end-joining pathway.

HSP, DNA/RNA Synthesis

Cytoskeletal Signaling, DNA Damage/DNA Repair, Metabolism, Cell Cycle/Checkpoint

2095401

0.9945

C18H22ClIN6O2S

548.83

Cl.IC=1C=C2OCOC2=CC1SC3=NC=4C(=NC=NC4N3CCCNC(C)C)N

-20°C

Ice Packs

Small Compound