PUC-10 - CAS 2095549-31-6

PUC-10 is a 5-HT6 receptor antagonist with a Ki of 14.6 nM and an IC50 of 32 nM. Computer simulations suggest that PUC-10 is orally active and capable of crossing the blood-brain barrier. It induces autophagy in SH-SY5Y cells by inhibiting the mTOR pathway. PUC-10 is applicable in the study of neurological disorders.

5-HT Receptor, mTOR, Autophagy

PI3K/Akt/mTOR signaling, Neuroscience, GPCR/G Protein, Autophagy

2095512

C31H31N3O4S

541.661

S(=O)(=O)(N1C=2C(C([C@@H](CN3CCN(CC3)C4=C(OC)C=CC=C4)O)=C1)=CC=CC2)C=5C6=C(C=CC5)C=CC=C6

-20°C

Ice Packs

Small Compound