Purinostat - CAS 1929583-17-4

Purinostat is a selective inhibitor of HDACI/IIb with potential anti-leukemic properties. Its mesylate form, Purinostat mesylate, is effective at inhibiting the survival of Ph+ leukemic cells and CD34+ leukemic cells derived from CML patients. Purinostat mesylate targets HDACI/IIb, impacting several crucial factors for leukemia stem cell (LSC) survival, such as c-Myc, β-Catenin, E2f, Ezh2, Alox5, and mTOR. Additionally, Purinostat mesylate enhances glutamate metabolism in LSCs by increasing GLS1.

HDAC

DNA Damage/DNA Repair, Chromatin/Epigenetic

1929562

C23H26N10O3

490.518

O=C(NO)C1=CN=C(N=C1)N(C)CC2=NC=3C(=NC(=NC3N4CCOCC4)C=5C=CC(N)=CC5)N2C

-20°C

Ice Packs

Small Compound