PV1162 - CAS 1093793-11-3

PV1162 is a Chk2-specific inhibitor characterized by a potency with an IC 50 value of 0.29 nM. It operates by specifically targeting the gatekeeper-dependent hydrophobic pocket behind the ATP-binding site (adenine-binding region) to inhibit ATP binding to Chk2, effectively suppressing the phosphorylation activity of Chk2. This compound has demonstrated potential for application in cancer therapy.

Chk

Cell Cycle/Checkpoint

1093779

C21H24N6O2

392.45

C(NC1=CC=C(\C(=N\NC(=N)N)\CCC)C=C1)(=O)C2=CC=3C(N2)=CC=C(OC)C3

-20°C

Ice Packs

Small Compound