PVD-06 - CAS 3032975-48-4

PVD-06 is a selective PROTAC-based degrader of PTPN2 (with a selectivity index of greater than 60-fold over PTP1B) and exhibits anticancer activity. It induces the degradation of PTPN2 through ubiquitination and proteasome-dependent pathways. PVD-06 also enhances T cell activation and amplifies IFN-γ-mediated cytotoxicity.

PROTACs, Phosphatase

PROTAC, Metabolism

3032923

C48H55F4N9O11S2

1074.13

C(C(O)=O)(F)(F)F.FC=1C2=C(C=C(O)C1N3S(=O)(=O)NC(=O)C3)C=CC(=C2)C4=CN(CC(NCCCCCC(N[C@H](C(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@@H](O)C5)[C@](C)(C)C)=O)=O)N=C4

-20°C

Ice Packs

PROTAC