PVTX-321 - CAS 3026004-38-3

PVTX-321 is an orally active estrogen receptor α (ERα) degrader. It effectively degrades ERα with a DC50 of 0.15 nM in MCF-7 cells and also shows inhibitory activity against ERα mutants with an IC50 of 59 nM. PVTX-321 holds potential for research in ER+/HER2- breast cancer.

Estrogen Receptor/ERR

Endocrinology/Hormones

3025963

C51H55FN4O6

839

C(N1CCC2(C=3C(OC2)=C4C(=CC3)C(=O)N(C4)[C@@H]5C(=O)NC(=O)CC5)CC1)C6CC7(C6)CCN(CC7)C8=CC(OC)=C(C=C8F)[C@H]9[C@H](CCC=%10C9=CC=C(O)C%10)C%11=CC=CC=C%11

-20°C

Ice Packs

Small Compound