PX-12 - CAS 141400-58-0

PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor growth in animal models. Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated as a potential cancer treatment in combination with chemotherapy for patients with advanced metastatic cancer. Initial trials correlated doses of Px-12 with increased patient survival.

Others, Apoptosis, Thioredoxin

Metabolism, Others, Apoptosis

141342

0.996

C7H12N2S2

188.31

CCC(C)SSc1ncc[nH]1

-20°C

Ice Packs

Small Compound