Pyridinium bisretinoid A2E - CAS 173449-96-2

Pyridinium bisretinoid A2E (A2E) is a fluorescent chromophore isolated from lipofuscin in retinal pigment epithelium, a lipophilic cation and weak photosensitizer with cytotoxicity. A2E promotes apoptosis under blue light exposure and induces autophagy under photoactivation, damaging membrane integrity in a concentration-dependent manner.

ROS, Autophagy, Photosensitizer, Apoptosis, Reactive Oxygen Species

Apoptosis, Autophagy, NF-κB, Immunology/Inflammation, Metabolism

173351

0.9819

C42H58NO

592.92

C(CO)[N+]=1C(/C=C(/C=C/C=C(/C=C/C=2C(C)(C)CCCC2C)\C)\C)=CC(/C=C/C=C(/C=C/C=3C(C)(C)CCCC3C)\C)=CC1

-20°C

Ice Packs

Small Compound