Pyridone 6 - CAS 457081-03-7

Pyridone 6 (JAK Inhibitor) (CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM) ; displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases.

JAK, Tyrosine Kinases

Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Stem Cells, Chromatin/Epigenetic

457081-03-7

0.9874

C18H16FN3O

309.34

CC(C)(C)c1nc2c([nH]1)c1ccc(F)cc1c1c2cc[nH]c1=O

-20°C

Ice Packs

Small Compound