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Molfinity

Pyrimidinone 8 - CAS 65004-42-4

Pyrimidinone 8 - CAS 65004-42-4

MF-0113483-01

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Product Details

  • Bioactivity

    Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of divalent metal transporter 1 (DMT1) with a Ki of 20 μM (hDMT1) . It does not affect the surface expression of hDMT1 and is not influenced by extracellular pH. Pyrimidinone 8 inhibits hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.

  • Target

    Ferroportin

  • Related Pathways

    Membrane transporter/Ion channel

  • CAS Number

    64958

  • Molecular Formula

    C10H12N4O

  • Molecular Weight

    204.229

  • SMILES

    O=C1N=C(NC(=C1)C)N2N=C(C=C2C)C

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound