PZ-1922 free base - CAS 1648745-65-6

PZ-1922 free base is a brain-penetrant 5-HT6R/5-HT3R antagonist with Ki values of 17 nM and 0.45 nM, respectively. It reversibly inhibits MAO-B (pIC50: 8.93) . In rat novel object recognition (NOR) tests, PZ-1922 free base counteracts Scopolamine (SCOP) -induced memory deficits and prevents Aβ-induced memory decline in T-maze tests.

5-HT Receptor, Monoamine Oxidase

GPCR/G Protein, Neuroscience

1648674

C22H21ClN4

376.88

ClC1=CC=CC(=C1)CN2C=CC=3C(=NC=4C=CC=CC4C32)N5CCNCC5

-20°C

Ice Packs

Small Compound